Web Reference: Nov 17, 2025 · The study provides strong evidence that 24 weeks of folinic acid supplementation improves autism severity and behavioural regulation in young children. Its excellent safety profile and biological plausibility make it a promising adjunct in the management of ASD, especially in those with folate receptor autoantibody positivity. Mar 24, 2026 · Folinic acid, also known as leucovorin, is a form of folate, a B vitamin crucial for various bodily functions, including DNA synthesis and repair. Its role in supporting neurological health has led to investigations into its potential benefits for children diagnosed with autism spectrum disorder. This interest stems from observations of metabolic differences in some individuals with autism and the potential for folinic acid to address these differences. Oct 1, 2025 · Leucovorin (folinic acid) is a reduced form of folate. Unlike folic acid, it can enter through alternative routes (such as RFC) when the main receptor (FRα) is blocked, helping restore folate levels in the central nervous system. It has been used for years as “rescue” after methotrexate and to treat CFD. PMC Why is it related to autism?
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