Web Reference: Feb 25, 2026 · Because mutations are random changes, they are expected to be mostly deleterious, but some may be beneficial in certain environments. In general, mutation is the main source of genetic variation, which is the raw material for evolution by natural selection. Mutations may or may not produce detectable changes in the observable characteristics (phenotype) of an organism. Mutations play a part in both normal and abnormal biological processes including: evolution, cancer, and the development of the immune system, including junctional diversity. 1 day ago · A mutation is a change in a DNA sequence. Mutations can result from DNA copying mistakes made during cell division, exposure to ionizing radiation, exposure to chemicals called mutagens, or infection by viruses.
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