Web Reference: Feb 20, 2026 · Many conditions and lifestyle factors can cause this common symptom. Jan 17, 2026 · Overview Myalgic encephalomyelitis/chronic fatigue syndrome, also called ME/CFS, is a complicated condition. It causes extreme fatigue that lasts for at least six months. Symptoms worsen with physical or mental activity but don't fully improve with rest. The cause of ME/CFS is unknown, although there are many theories. Experts believe it might be triggered by a combination of factors. Jan 17, 2026 · Diagnosis There's no single test to confirm a diagnosis of myalgic encephalomyelitis/chronic fatigue syndrome, also called ME/CFS. Symptoms can mimic those of many other health conditions, including: Sleep disorders. Fatigue can be caused by sleep disorders. A sleep study can determine if your rest is being disturbed by conditions such as obstructive sleep apnea, restless legs syndrome or ...
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