Cracking the Code

Web Reference: The Cracking the Code Forum is a place to talk guitar technique, explore the intersection of musical art and science, and learn from one another. Jul 11, 2025 · I’ve got a student who’s been on a massive Eric Johnson kick lately, and lucky for him (and me!), CTC has given me a wealth of fantastic information to pass along. I’m really proud of the kid; he’s leveled his playing up to incredible levels since he discovered EJ’s music. However: I’ve been looking for tabs for CoD that are as accurate to EJ’s own playing of it as possible, and ... The Cracking the Code Forum is a place to talk guitar technique, explore the intersection of musical art and science, and learn from one another.

YouTube Excerpt: This video presents research introducing BRAIN-MAGNET, a novel functional genomics atlas combined with a convolutional neural network (CNN) model, developed to enhance the clinical interpretation of non-coding regulatory elements (NCREs) involved in disease. Researchers used ChIP-STARR-seq to functionally annotate over 145,000 NCREs in human neural stem cells (NSCs), modelling early brain development, and identified that highly active NCREs show increased sequence constraint and enrichment for specific transcription factor motifs. BRAIN-MAGNET was trained on this empirical data to predict NCRE activity based on DNA sequence, facilitating the prioritisation of potential disease-causing rare non-coding variants from sources like the Genomics England 100,000 Genomes Project. The study demonstrates the model's utility in fine-mapping GWAS loci and identifying enhanceropathies, such as a non-coding variant linked to Charcot-Marie-Tooth disease, offering a tool to reduce missing heritability in human genetics. Experimental validation confirmed that nucleotides predicted to be functionally relevant by BRAIN-MAGNET significantly impact NCRE activity when mutated.

This video presents research introducing BRAIN-MAGNET, a novel functional genomics atlas combined with a convolutional neural network (CNN) model,...

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