Web Reference: Dec 23, 2025 · Complications from cholestasis of pregnancy appear to be due to high bile acid levels in the blood. Complications may occur in the mom, but the developing baby is especially at risk. Mar 27, 2026 · Cholestasis of pregnancy is a condition that causes bile to build up in your gallbladder, liver and bloodstream. It can cause severe itching and other complications during pregnancy. Patients with Intrahepatic Cholestasis of Pregnancy are at approximately a 5 times increased risk of developing preeclampsia. This risk increases with more elevated bile acid levels and is most common when bile acid levels are over 40 micromol/L.
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